Postcoital Contraception With DES

Postcoital Contraception With Diethylstilbestrol, 1971


A follow-up study was made of 1000 women of child-bearing age who were given, within 72 hours of sexual exposure, 25 mg of diethylstilbestrol twice daily for 5 days, by the University of Michigan Health Service in 1967, to determine frequency and nature of side effects and the character of the following menses.

No pregnancies resulted and no serious side effects were reported. 44% of the participants reported slight or intermittent nausea; 31.5% reported no side reactions at all.

40% of the participants had normal menses following use of the diethylstilbestrol, and no serious irregularities were reported.

Tables are also provided giving time of sexual exposure in relation to the menstrual cycle, and the prophylaxis used in the individual case, if any.

Patients were reminded that diethylstilbestrol is an emergency contraceptive treatment and were encouraged to seek other means of contraception if regularly needed.


  • Postcoital Contraception With Diethylstilbestrol, JAMA Network PMID: 12275928, October 25, 1971.

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