Menstrual History of Young DES Daughters

Is oligomenorrhea associated with DES exposure ?

1979 Study Abstract

The menstrual histories of 218 patients exposed in utero to diethylstilbestrol (DES) were compared with those of 158 control subjects.

  • No significant differences were revealed in the complaint of menstrual irregularities at either the initial or follow-up examination.
  • Age at menarche was the same in both groups, and was the same as found in the United States as a whole.

These findings differ from the report of a controlled trial in Chicago which suggests that there is a specific pattern of oligomenorrhea associated with DES exposure.


  • Menstrual history of young women exposed in utero to diethylstilbestrol, Fertility and sterility, NCBI PubMed PMID: 467695, 1979.
  • Featured image Annie Spratt.

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