Intrauterine factors and breast cancer risk

Breast cancer increased risk in DES offspring


“Suggestions that risk of breast cancer in human beings might be affected by early-life exposures, or even intrauterine events and conditions, have been reported in published studies in the past four decades, …

… More direct evidence in support of a role of pregnancy oestrogens has been provided by the results from a unique cohort of women in utero exposed to diethylstilbestrol, a synthetic oestrogen. These women were found to be at increased risk for breast cancer after the age of 40 years, when familial breast cancer becomes rare.”



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