DES contraceptive effects

On the mechanism of the contraceptive action of oestrogens administered after ovulation

1973 Study Abstract

The antifertility effects of estrogens in animals has long been known, but it was not until 1966 that the effects of estrogen in man became known as well.

The estrogen effects during the time of the transport of the egg through the fallopian tubes to the uterine cavity was studied. 50 mg of diethylstilbestrol (DES) was administered daily during the 5-day postovulatory period.

The results were

  • a shortening of the cycle,
  • a lowering of plasmic progesterone,
  • and a decrease in the secretion of pregnanediol.
  • The development of the endometrium stopped.

These results indicate that DES, when given at this time, shortens the function of yellow corpuscles and affects the further development of the endometrium. Either of these mechanisms could explain the contraceptive effects of the estrogen.

Sources

  • On the mechanism of the contraceptive action of oestrogens administered after ovulation , Ceskoslovenska gynekologie, PMID: 4765140, 1973 Sep.
  • Image credit The Roaming Platypus.
DES DIETHYLSTILBESTROL RESOURCES

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