DES and Cardiovascular Endocrine Disease

Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement, 2009

Abstract

The human evidence for BPA is mounting; recently, Lang et al. published a cross-sectional analysis on the relationship between concentrations of urinary BPA and chronic disease states in over 1400 adults in the United States. They found a significant correlation between BPA concentrations in urine with cardiovascular disease and abnormal concentrations of liver enzymes. It would be really interesting to be able to relate the relationship of these outcomes with developmental/fetal exposure to BPA and other xenobiotics.

However, epidemiological research on fetal exposure would be logistically difficult and costly because exposures must be measured at several different time points, including gestation, whereas the outcome may not be manifest in some cases until 50 or more years after the initial fetal exposure. Given the reproducibility of the human DES syndrome in rodents and recent evidence for commonalities in a relationship between BPA and cardiovascular endocrine disease, it is obvious that more research in animal models is necessary to enrich our knowledge of the mechanisms by which endocrine disruptors increase the risk of disease.

References

  • Full study (free access) : Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement, Endocrine Reviews, NCBI PubMed PMC2726844, 2009 Jun.
  • Featured image Cerys Lowe.
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