Testicular tumors response to DES treatment

Carcinogenic effects of diethylstilbestrol in male Syrian golden hamsters and European hamsters, 1979

Abstract

The tumorigenic effects of sc-implanted diethylstilbestrol (DES) on male Syrian golden hamsters and European hamsters were compared.

The adenohypophyses, kidneys, and testes of both species showed neoplastic responses to DES treatment.

European hamsters were more sensitive than were Syrian hamsters, in as much as the European hamsters had a higher tumor incidence.

The testicular tumors were all Leydig cell adenomas and seemed to depend on the coincident occurrence of hypophyseal neoplasms (all composed of gonadotropic cells).

Of the European hamsters tested, 29% also developed liver tumors (hepatocellular adenomas, carcinomas, and cholangiocarcinomas.

References

  • Carcinogenic effects of diethylstilbestrol in male Syrian golden hamsters and European hamsters, Journal of the National Cancer Institute, NCBI PubMed, PMID: 398263, 1979.
  • Featured image credit Ricky Kharawala.
DES DIETHYLSTILBESTROL RESOURCES

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