Susceptibility of Seven Inbred Strains and the F1 Hybrids to Estrogen-Induced Testicular Tumors and Occurrence of Spontaneous Testicular Tumors in Strain BALB/c Mice, 1960
Abstract
Strain BALB/c mice are susceptible to the development of estrogen-induced interstitial-cell testicular tumors.
Mice of this strain and 6 other inbred strains were tested for susceptibility to these tumors by subcutaneous implantation of pellets containing 20 percent diethylstilbestrol in cholesterol.
Strain BALB/c mice (incidence = 80%) were far more susceptible than the most susceptible (strain DBA/2 = 12%) of the other strains.
F1 hybrids derived by mating BALB/c females to males of the 6 other strains were tested for susceptibility by the same procedure.
Those procured from strain DBA/2 (incidence = 67%) or strain Y (incidence = 65%) were the most susceptible and those from strain I (incidence = 3%) or strain RIII (incidence = 0%) were the most resistant. The incidence of gross spontaneous testicular tumors in 154 BALB/c mice was 0 percent. Three mice had microscopic lesions of the testes. In a testis of one, connective-tissue elements predominated. Testes of the other 2 mice contained small areas of interstitial-cell hyperplasia.
References
- Susceptibility of Seven Inbred Strains and the F1 Hybrids to Estrogen-Induced Testicular Tumors and Occurrence of Spontaneous Testicular Tumors in Strain BALB/c Mice, JNCI: Journal of the National Cancer Institute, Volume 25, Issue 5, Pages 1069–1081, doi.org/10.1093/jnci/25.5.1069, November 1960.
- Featured image credit immuno-oncologynews.
DES DIETHYLSTILBESTROL RESOURCES
- Source DES and testicular cancer studies.
- Diethylstilbestrol DES studies by topics.