Diethylstilboestrol exposure and testicular cancer

International Journal of Epidemiology, 1989


The postulated association between exposure to diethylstilboestrol (DES) in utero and testicular cancer is an attractive hypothesis—especially since exposure to DES and the subsequent development of vaginal cancer has been established as cause and effect.

The cases (A case-control study of testicular cancer using Connecticut tumour registry data) were patients diagnosed between 1945 and 1980 as having testicular cancer, and born between 1945 and 1972.

As the authors acknowledged, other studies are needed to conclusively answer the question of whether DES is a causal factor in the aetiology of testicular cancer.


  • Diethylstilboestrol exposure and testicular cancer, International Journal of Epidemiology, NCBI PubMed, PMID: 2767864, 1989.
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