Prenatal DES exposure and breast cancer

Risk of breast cancer in women prenatally exposed to diethylstilbestrol

2012 Study Abstract

Diethylstilbestrol (DES) is a synthetic estrogen prescribed to prevent miscarriages until 1977.

Its role in the development of vaginal adenocarcinoma and cervical dysplasia is known and screening codified.

Recent cohort studies show that exposure to DES in utero increases breast cancer risk especially after 40 years.

This article reports the observation of a breast cancer of exceptional gravity in a patient exposed to DES in utero. It details the risk of breast cancer for “DES daughters” and support possible screening modalities.


  • Prenatal diethylstilbestrol exposure and breast cancer, Gynécologie, obstétrique & fertilité, NCBI PubMed PMID: 23102737, 2012 Dec.
  • Featured image credit artranked.

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