Possibility of postconception control of fertility using medicamentous nidation inhibitors
1973 Study Abstract
Clinical aspects of postconception fertility control are reviewed. Estrogens (ethinyl estradiol and diethylstilbestrol) have been used for this purpose. In addition to their undesirable side effects, they must be administered within a strictly defined time period.
Several progestagens have been used as postcoital contraceptives, but they too are effective only when administered a few days after ovulation.
A number of nonsteroidal substances appear promising, as inhibitors of implantation and as abortifacient agents.
Prostaglandins also appear promising because of similar properties. Oral administration is not feasible, but vaginal administration is an attractive possibility. But the high incidence of side effects and somewhat unreliable effects are problems. The mechanisms of action of all these substances have not been explained.
Sources
- Possibility of postconception control of fertility using medicamentous nidation inhibitors, Zentralblatt fur Gynakologie, PMID: 4131008, 1973 Dec.
DES DIETHYLSTILBESTROL RESOURCES
- Source DES and pregnancy studies.
- Diethylstilbestrol DES studies listed by topics and date of publication.