DES use as a postcoital contraceptive agent, 1970

Endometrial Carbonic Anhydrase After Diethylstilbestrol as a Postcoital Antifertility Agent

1970 Study Abstract

Others have shown that the oral administration of diethylstilbestrol 25 mg daily for 5 days is an effective postcoital antifertility method.

This dose of the estrogen was started in 4 volunteers on the day basal temperature rose.

Endometrial carbonic anhydrase, 5 days after the temperature rise, was lowered to an average of 9.8 enzyme units (EU)/g as compared to the average control value of 21.2 EU/g.

This decreased carbonic anhydrase activity may represent a barrier to implantation, although other antifertility mechanisms may also be activated by diethylstilbestrol.

Sources

  • Endometrial Carbonic Anhydrase After Diethylstilbestrol as a Postcoital Antifertility Agent, Obstetrics & Gynecology, greenjournal, September 1970.
  • Featured image credit Nicholas Gercken.
DES DIETHYLSTILBESTROL RESOURCES

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