Lesions of testis and epididymis associated with prenatal diethylstilbestrol exposure

Environmental health perspectives, 1988

Study Abstract

Cryptorchidism and retention of Müllerian duct structures occur with high frequency among the male offspring of CD-1 mice treated with 100 micrograms diethylstilbestrol/kg body weight on days 9 through 16 of pregnancy. Hyperplasia of the rete testis and Müllerian duct structures were found in many of the DES-treated male mice, as was a low but significant number of reproductive tract neoplasms.

A persistent Mullerian duct syndrome has been described in human males, usually associated with cryptorchidism and Leydig cell hyperplasia. These men may have uteri, oviducts, and the upper one-third of the vagina.

Sources

  • Full text (free access) : Lesions of testis and epididymis associated with prenatal diethylstilbestrol exposure, Journal of obstetric, Environmental health perspectives, NCBI PubMed, PMC1474522, 1988.
DES DIETHYLSTILBESTROL RESOURCES

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