Environmental health perspectives, 1988
Cryptorchidism and retention of Müllerian duct structures occur with high frequency among the male offspring of CD-1 mice treated with 100 micrograms diethylstilbestrol/kg body weight on days 9 through 16 of pregnancy. Hyperplasia of the rete testis and Müllerian duct structures were found in many of the DES-treated male mice, as was a low but significant number of reproductive tract neoplasms.
A persistent Mullerian duct syndrome has been described in human males, usually associated with cryptorchidism and Leydig cell hyperplasia. These men may have uteri, oviducts, and the upper one-third of the vagina.
- Full text (free access) : Lesions of testis and epididymis associated with prenatal diethylstilbestrol exposure, Journal of obstetric, Environmental health perspectives, NCBI PubMed, PMC1474522, 1988.