DES persistent impairment of several immunological parameters

Decreased and disproportionate T-cell population in adult mice after neonatal exposure to diethylstilbestrol

1980 Study Abstract

Female Balb/c mice neonatally treated with diethylstilbestrol show persistent impairment of several immunological parameters.

The distribution of different classes of lymphocytes in the spleen has been determined at 6, 12, and 18 weeks of age.

DES resulted in a decreased percentage of T cells in spleen while the number of B cells was normal.

Utilizing Lyt antisera the T-cell subpopulations were found to be imbalanced with an increase in Lyt 123 cells and a concomitant decrease in Lyt 1 cells.

Ovariectomy did not influence the diethylstilbestrol-induced alterations in the T-lymphocyte population.

Sources and more information
  • Decreased and disproportionate T-cell population in adult mice after neonatal exposure to diethylstilbestrol, Cellular Immunology, Volume 51, Issue 1, Pages 55-63, April 1980.
  • Impaired T-cell featured image credit bloodjournal.
DES DIETHYLSTILBESTROL RESOURCES

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