Teratogenesis and carcinogenesis in rat offspring after transplacental and transmammary exposure to diethylstilbestrol, 1979
Transplacental and transmammary exposure of tat offspring to diethylstilbestrol (DES) was studied in regard to potential teratogenesis and carcinogenesis.
Pregnant and/or lactating rats received DES in oil subcutaneously.
- In females so exposed, abnormal development of the urogenital sinus (hypospadias and urethrovaginal cloaca formation) occurred.
- In exposed male offspring, hypospadias, phallic hypoplasia, inhibition of growth and descent of testes, as well as abnormalities of Wolffian derivatives, were observed.
- In 20–40 per cent of DES-exposed female offspring, vaginal adenosis, endometrial squamous metaplasia, and genital malignancy were encountered. Two DES-exposed offspring had a vaginal squamous carcinoma, one had an endometrial adenocarcinoma, and one had an ovarian adenocarcinoma. Vaginal squamous carcinomas may have originated in foci of squamous metaplastic epithelium of vaginal adenosis.
- None of the control rats developed genital malignancy.
- Teratogenesis and carcinogenesis in rat offspring after transplacental and transmammary exposure to diethylstilbestrol, NCBI PubMed PMID: 454458, 1976.
- Featured image credit Taton Moïse.