Drug exposure, pregnancy outcome and fetal and childhood development occurring in the offspring of mothers with systemic lupus erythematosus and other chronic autoimmune diseases
2006 Study Abstract
Most autoimmune diseases occur more commonly in females and many of these young women wish to become mothers. For pregnancy to proceed successfully immunomodulation and physiological changes preparing the reproductive system need to occur.
Pregnancy occurring in a chronically ill mother who requires medications in order to maintain her own health and who may have already incurred significant organ pathology gives rise to several problems and so four questions arise:
- What will be the effect of the pregnancy on the underlying disease?
- What will be the effect of the disease on the outcome of pregnancy?
- How to manage the disease, just prior to, throughout and immediately after the pregnancy?
- The long term fetal and childhood effects of maternal disease and its management.
This paper reviews the current literature pertaining to these questions in patients with systemic lupus erythematosus (SLE) and other chronic rheumatic and autoimmune diseases.
Diethylstilbestrol
… “Other evidence suggests that the risk of autoimmune disease, particularly Hashimotos thyroiditis, is also increased in individuals exposed to DES in utero.” …
References
- Drug exposure, pregnancy outcome and fetal and childhood development occurring in the offspring of mothers with systemic lupus erythematosus and other chronic autoimmune diseases, Lupus, NCBI PubMed, PMID: 17153855, 2006.
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DES DIETHYLSTILBESTROL RESOURCES
- Source DES and autoimmune diseases studies.
- Diethylstilbestrol DES studies by topics.
I am 55 and was just diagnosed with Hashimotos. I was diagnosed hypothyroid in 2007. The first thing I did today was research to see if the DES in utero could be a contributing factor. Just what I thought. This has been a lifelong nightmare of misery and and I’m so tired of all the suffering.
Thank you so much for sharing your testimonial with our readers, Brenda, it’s highly appreciated.
Best wishes,
I recently found out my daughter had DES exposure through placenta or breast milk at two months old. I almost lost her. She is 16 and I just found out about DES exposure.
Her father told her current doctor that they don’t make it anymore and to take it off her record.
I knew none of this.
I found they prescribe it for female dogs for continance issues.
When my daughter was 15 she got severely sick. Dizzy spells. Her father told the doctor he believed the problem was hormonal. Her thyroid was low. When she was 9 a lump was found in her breast.
I was never able to have children after her. They thought I had lupus when pregnant.
My knee attacked itself causing it to fill with blood while I was pregnant
I have problems with my thyroid and had two breast lumps after having her.
Her father had it removed from her record and when I finally found out he lied to me about what it was saying he had no idea it was on her record.
I know he druggged me. I believe he’s used the medicine to make me and her sick. I am in menopause and I am 42. No one believes me. How can I convince doctor to listen to me so she can get the care she needs.
Hi Darlene, I don’t know how you can.
But if you are on Facebook, there are a few groups – such as this one – with DES-affected/exposed people, who might give you some advice and support.
Best wishes,