DES-offspring genetic issues mentioned since 1980 at least…
A study in an article by Barnes pointed out that women who were the products of pregnancies with complications treated with DES had worse outcomes in their own pregnancies than did controls.
That is compatible with the assumption of a familial tendency to have an unfavorable outcome of pregnancy.
If one assumes that the physicians who were treating the mothers with DES were accurate in the clinical diagnosis of complicated pregnancies and the DES treatment did some good, the saved offspring inherited the affected genes and could be expected to have unfavorable pregnancies themselves.
Some of the women who are portrayed as victims of DES should be thankful that they are alive and able to have pregnancies with unfortunate outcomes instead of having been unfortunate outcomes themselves.
- Sources: NCBI PubMed PMID: 7383113, 1980 Jul.