DES exposure linked to disordered gene expression and eventual neoplastic transformation

Deceased numbers of spindle and cytoplasmic microtubules in hamster embryo cells treated with a carcinogen, diethylstilbestrol

Abstract

Diethylstilbestrol (DES) has been shown to induce neoplastic transformation in the absence of measurable mutations at specific loci in Syrian hamster embryo cells.

It has been proposed that DES induces cell transformation via the production of aneuploidy.

In the present study we document that concentrations of DES that cause aneuploidy also produce abnormal or arrested mitotic spindles.

Thus, DES may disrupt spindle microtubules and produce aneuploidy that results in disordered gene expression and eventual neoplastic transformation.

  • Download the full study (free access) Deceased numbers of spindle and cytoplasmic microtubules in hamster embryo cells treated with a carcinogen, diethylstilbestrol, Cancer research Volume 46, Issue 4 Part 2, 1986.
  • Identification of Gene Expression Signature in Estrogen Receptor Positive Breast Carcinoma image credit Libertas Academica.
DES DIETHYLSTILBESTROL RESOURCES

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