Cardiovascular birth defects and antenatal exposure to female sex hormones

The New England journal of medicine, 1977

Abstract

In a cohort of 50,282 pregnancies 19 children with cardiovascular defects were born to 1042 women who received female hormones during early pregnancy (18.2 per 1000).

Among 49,240 children not exposed in utero to these agents there were 385 with cardiovascular malformations (7.8 per 1000).

Six children with cardiovascular defects were born to a sub-group of 278 women who used oral contraceptives during early pregnancy (21.5 per 1000).

After the data were controlled for a wide variety of potentially confounding factors by multivariate methods, the association between in utero exposure to female hormones and cardiovascular birth defects was statistically significant.

Reference

  • Cardiovascular birth defects and antenatal exposure to female sex hormones, NCNI PubMed, PMID: 830309, 1977 Jan 13.
DES DIETHYLSTILBESTROL RESOURCES

Have your say ! Share your views

This site uses Akismet to reduce spam. Learn how your comment data is processed.