Atypical gene expression after DES-exposure early in development

Prenatal exposure of male mice to diethylstilbestrol alter the expression of the lactotransferrin gene in seminal vesicles

Abstract

We have previously isolated an estrogen-inducible secretory protein, lactotransferrin (LTF), and a cDNA to its messenger RNA from the uterus of mice.

In this report we determined that the level of LTF mRNA is minimal in the seminal vesicles of normal mice.

In contrast, expression of LTF mRNA in the seminal vesicles of developmentally estrogenized males was both constitutive and estrogen inducible.

The results suggested that this alteration may be an example of atypical gene expression after hormonal manipulation early in development.

  • Prenatal exposure of male mice to diethylstilbestrol alter the expression of the lactotransferrin gene in seminal vesicles, Molecular endocrinology (Baltimore, Md.), NCBI PubMed PMID : 3216864, 1988 Dec.
  • Featured image credit Steph Hillier.
DES DIETHYLSTILBESTROL RESOURCES

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