The effect of adult exposure to diethylstilbestrol in the mouse, 1980
Female adult mice were administered diethylstilbestrol (DES) at dosages of 0.2, 2.0 and 8.0 mg/kg body weight per day for 5 consecutive days.
A dose-related alteration in immunologic function occurred as a consequence of DES exposure and included depression of Ab responses, cutaneous delayed hypersensitivity and in vitro lymphoproliferative responses to mitogens as well as allogeneic leukocytes in one-way mixed leukocyte cultures.
The percentage of splenic leukocytes possessing a T cell membrane marker was decreased following DES exposure although the percentage of cells with B cell markers was normal.
Co-culture studies indicated that immune depression is due, at least in part, to induction of suppressor cells that reside in the adherent cell population although an additional effect of DES on T lymphocytes is also probable.
- The effect of adult exposure to diethylstilbestrol in the mouse: Alterations in immunological functions, Journal of the Reticuloendothelial Society, NCBI PubMed, PMID: 6450833, 1980 Dec.
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