Understanding sexual differentiation of the human brain

DES exposure associated with reduced hemispheric laterality and lowered spatial ability

1992 Study Abstract

Ten males exposed to diethylstilbestrol (DES), a nonsteroidal synthetic estrogen, during gestation were compared to their matched, unexposed brothers on measures of brain hemispheric specialization for processing nonlinguistic spatial information and cognitive abilities.

Effects of prenatal exposure to diethylstilbestrol (DES) on hemispheric laterality and spatial ability in human males, US National Library of Medicine, Hormones and behavior, NCBI PubMed PMID: 1563729, 1992 Mar.

Image credit bluhousworker.

DES exposure was associated with reduced hemispheric laterality and lowered spatial ability.

These data provide direct evidence of a relationship between brain laterality, spatial cognitive ability, and prenatal exposure to hormones in human males. Further, the implications of these findings for understanding sexual differentiation of the human brain are discussed.

More DES DiEthylStilbestrol Resources

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