Reproductive tract lesions in male mice exposed prenatally to DES

DES Sons should be further evaluated for latent alterations of the genital tract, 1975

Abstracts

Sixty percent of the male offspring from pregnant mice treated with diethylstilbestrol during gestation were sterile. The affected animals had gonadal changes which included intra-abdominal or fibrotic testes, or both. Additionally, nodular masses in the ampullary region of the reproductive tract were observed in 6 of 24 animals; one of these appeared to be preneoplastic.

… “Eight animals had epididymal cysts; six of these also had testicular lesions.” …

… “In light of these results in rodents, the incidence of cryptorchidism in young boys whose mothers had been treated with DES during gestation may be of clinical importance. Obviously, these offspring should be further evaluated for latent alterations of the genital tract, since changes in the adult male human reproductive tract similar to those we observed in the mouse might be dismissed as secondary to inflammation. Some of these lesions could be important causes of infertility even when viable sperm are produced.” …

References

  • Reproductive tract lesions in male mice exposed prenatally to diethylstilbestrol, Science, NCBI PubMed, PMID: 242076, 1975 Dec 5.
  • Featured image credit quantamagazine.
DES DIETHYLSTILBESTROL RESOURCES

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