Effect of Diethylstilbestrol on Reproductive Function

American Society for Reproductive Medicine, Fertility and Sterility, 1999

Study Abstract

Objective
To review the effects of in utero exposure to diethylstilbestrol (DES) on müllerian development and subsequent reproductive function.

Design
The literature on DES and reproductive function was reviewed and summary data are presented. The studies were identified through the computerized MEDLINE database and a manual search of relevent bibliographies.

Result(s)
In utero exposure to DES resulted in reduced fertility and increased rates of ectopic pregnancy, spontaneous abortion, and preterm delivery.

Conclusion(s)
An understanding of the reproductive performance of women who were exposed to DES in utero is useful for counseling these patients regarding their risks and treatment options.

Sources

DES DIETHYLSTILBESTROL RESOURCES

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