Feminization of the male mouse reproductive tract after prenatal exposure to DES
1988 Study Abstract
We have previously isolated an estrogen-inducible secretory protein, lactotransferrin (LTF), and a cDNA to its messenger RNA from the uterus of mice.
Prenatal exposure of male mice to diethylstilbestrol alter the expression of the lactotransferrin gene in seminal vesicles, US National Library of Medicine National Institutes of Health, Molecular endocrinology (Baltimore, Md.), NCBI PubMed PMID: 3216864, 1988 Dec.
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In this report we determined that the level of LTF mRNA is minimal in the seminal vesicles of normal mice.
In contrast, expression of LTF mRNA in the seminal vesicles of developmentally estrogenized males was both constitutive and estrogen inducible.
The mRNA for the major estrogen-inducible uterine secretory protein, lactoferrin (LF), was constitutively expressed in the seminal vesicle of male mice exposed prenatally to DES, but not in the seminal vesicle of control mice. The results suggested that this alteration may be an example of atypical gene expression after hormonal manipulation early in development.