Outcome of pregnancy in patients exposed in utero to diethylstilbestrol

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A comparison of the DES-exposed pregnancy experience in France and in the United States, by the CNGOF – Collège National des Gynécolgues et Obstétriens Français.

Abstract

Outcome of pregnancy in patients exposed in utero to diethylstilbestrol. Survey by the National College of French Gynecologists and Obstetricians, Journal de gynécologie, obstétrique et biologie de la reproduction, NCBI PubMed PMID: 3294279, 1988.

This study analyses the outcome of 110 pregnancies that occurred in 57 patients who were exposed to DES (DiEthylStilboestrol) during their fetal life.

The quantities of Distilbene that were received in the first trimester of the pregnancy were the same in France and in the United States.

The obstetrical complications of exposure in utero to DES were identically the same in France and in the United States.

  • Of particular note is the high level of extra-uterine pregnancies (15%)
  • and of 1st and 2nd trimester miscarriages (42%).
  • Only 41% of the population exposed to DES delivered a live baby.

It is estimated that 80,000 women were exposed to it in France. Exposure in utero to DES has given rise to a public health problem.

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