Neonatal DES exposure caused the differential expression of 900 genes

EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals


“Synthetic estrogens are well known disruptors of uterine structure and function in humans and animals. Consistent with previous studies, recent data indicate that neonatal DES exposure caused endometrial hyperplasia/dysplasia in hamsters and increased uterine adenocarcinoma and uterine abnormalities in Donryu rats. Neonatal DES exposure also caused the differential expression of 900 genes in one or both layers of the uterus. Specifically, DES altered multiple factors in the PPARγ pathway that regulate adipogenesis and lipid metabolism, and it perturbed glucose homeostasis, suggesting that DES affects energy metabolism in the uterus. In the mouse uterus, DES altered the expression of chromatin-modifying proteins and Wnt signaling pathway members caused epigenetic changes in the sine oculis homeobox 1 gene, and decreased the expression of angiogenic factors. DES also altered the expression of genes commonly involved in metabolism or endometrial cancer in mice, and it activated nongenomic signaling in uterine myometrial cells  and increased the incidence of cystic glands in rats.” …

… “The epidemiological data on potential links between EDCs and neurodevelopmental disorders have grown in the past 5 years; although we will focus on recent studies, we will also present results (briefly) from older studies for an historical perspective. The nature of this work generally involves measurements of body burden from maternal media (urine, blood, milk), umbilical cord blood, infant urine, and ultimately, a correlation with some neurodevelopmental measure in the child such as tests of cognitive function.” …

… “What is still very controversial is whether there are direct links among environmental EDCs and specific disorders such as autism spectrum disorders, attention deficit hyperactivity disorders, and others, although the hypothesis has been postulated that EDCs may contribute to the increasing prevalence of these disorders. A recent review has covered the subject of how aberrant prenatal steroid hormone levels produced by the mother, placenta, or fetal adrenal or gonad, along with pharmaceuticals and to a lesser extent EDCs, could affect the developing brain of the fetus in humans.” …

  • Read and download the full study (free access) EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals, on the NCBI, PubMed, Endocrine Reviews, PMC4702494, 2015 Dec.
  • Image credit NCBI PubMedPMC4702494/figure/F4.

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