Neonatal acute myeloid leukemia in an infant whose mother was exposed to diethylstilboestrol in utero
2009 Study Abstract
We report on an acute myeloid leukemia in a neonate whose mother was exposed to diethylstilboestrol in utero.
The newborn presented with leukemia cutis, hemorrhagic skin lesions, hyperleucocytosis and disseminated intravascular coagulation. A bone marrow examination confirmed the diagnosis of acute monocytic leukemia with a t(11;19) MLL-ELL fusion transcript. Chemotherapy was initiated but the child developed a bilateral pulmonary infection that led to fatal respiratory distress.
This case shows acute myeloid leukemia and the third pediatric leukemia reported after maternal diethylstilboestrol exposure.
Sources and more information
- Neonatal acute myeloid leukemia in an infant whose mother was exposed to diethylstilboestrol in utero, Pediatric blood & cancer, NCBI PubMed PMID: 19405140, 2009 Aug.
- Acute myeloid leukemia featured image credit omicsonline.