Effects of Mullerian anomalies on in vitro fertilization outcome, Journal of assisted reproduction and genetics, NCBI PubMed PMID: 11699126, 2001 Oct.
Full text: Journal of Assisted Reproduction and Genetics, Vol. 18, No. 10, 2001 PMC3455312, May 7, 2001.
To assess the effect of Mullerian anomalies on pregnancy rates in women undergoing in vitro fertilization (IVF).
The records of 37 patients with and 819 patients without Mullerian anomalies undergoing a first cycle of IVF between December 1995 and July 1998 were included in this retrospective study. Outcome variables included maximal estradiol level, number of days of stimulation, number of follicles, number of oocytes, fertilization rate, and ongoing/livebirth pregnancy rate.
Patients with Mullerian anomalies had a significantly lower ongoing pregnancy rate (8.3%) than did controls (24.8%). No patients with diethylstilbestrol (DES)-related anomalies had an ongoing pregnancy.
Among women with Mullerian anomalies, those with DES exposure in utero demonstrated the poorest outcome, with no ongoing pregnancies in 22 cycles. Physicians should use this information in counseling such patients about reproductive choices.
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