Complications of pregnancy in mice exposed prenatally to DES, Teratology, NCBI PubMed PMID: 6845221, 1983 Feb.
Women exposed prenatally to diethylstilbestrol (DES) develop a variety of reproductive tract anomalies. Most of these anomalies have been replicated in strain CD-1 mice after similar DES exposure.
Recently, impaired reproductive performance in DES-exposed women has been reported. To see whether the mouse model also replicates this defect, a study of reproduction was performed. Pregnant CD-1 mice were injected with DES and their female offspring were raised to breeding age. The latter were then exposed continuously to untreated males for a maximum of 4 months.
Among 74 mated mice,
- 34 became pregnant
- and 11 of these pregnancies ended in abortion or stillbirth.
Other anomalies encountered were:
- two fetuses with compressed heads,
- one of which seemed blocked from delivery by a vaginal adenocarcinoma;
- two uterine tumors,
- one of which was a teratocarcinoma;
- two teratomas located in uterine lumina;
- and two uteri containing placentas without embryos.
Since the frequency of successful pregnancies in the DES-exposed mice was reduced below control levels to a degree similar to that reported for DES-exposed women, the validity of the mouse model has been confirmed for this characteristic.