Comparison of Pregnancy Experience in DES-Daughters and unexposed Women

pregnant image
In this 1980 study, the difference in pregnancy outcomes between the DES daughters and the unexposed is highly significant. Pregnant.


A comparison of pregnancy experience in DES-exposed and DES-unexposed daughters

The Journal of reproductive medicine, NCBI PubMed,  PMID:7359503, 1980 Feb.

Reproductive histories were compared for 226 DES-exposed and 203 -unexposed daughters whose mothers participated in a double-blind evaluation 27 years before.

  • Irregular menstruation was slightly more common among the exposed (10%) than among the unexposed (4%).
  • Nineteen of the exposed and only four of the unexposed had primary infertility.
  • Among those at risk, 86% of the unexposed and 67% of the exposed had become pregnant. The reasons for these differences are not known.
  • Comparison of evaluable first pregnancy outcome revealed full-term live birth to be more common among the unexposed (85%) than the exposed (47%).
  • Premature live birth was experienced by 22% of the exposed but only 7% of the unexposed.
  • Nonviable outcomes of stillbirth, neonatal death, miscarriage and ectopic pregnancy occurred in 31% of the exposed and 8% of the unexposed.

The difference in pregnancy outcomes between the groups is highly significant. The DES-exposed with transverse cervicovaginal ridges were more likely to experience a nonviable outcome. Overall 82% of the exposed and 93% of the unexposed had at least one live offspring.

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