A comparison of pregnancy experience in DES-exposed and DES-unexposed daughters
The Journal of reproductive medicine, NCBI PubMed, PMID:7359503, 1980 Feb.
Reproductive histories were compared for 226 DES-exposed and 203 -unexposed daughters whose mothers participated in a double-blind evaluation 27 years before.
- Irregular menstruation was slightly more common among the exposed (10%) than among the unexposed (4%).
- Nineteen of the exposed and only four of the unexposed had primary infertility.
- Among those at risk, 86% of the unexposed and 67% of the exposed had become pregnant. The reasons for these differences are not known.
- Comparison of evaluable first pregnancy outcome revealed full-term live birth to be more common among the unexposed (85%) than the exposed (47%).
- Premature live birth was experienced by 22% of the exposed but only 7% of the unexposed.
- Nonviable outcomes of stillbirth, neonatal death, miscarriage and ectopic pregnancy occurred in 31% of the exposed and 8% of the unexposed.
The difference in pregnancy outcomes between the groups is highly significant. The DES-exposed with transverse cervicovaginal ridges were more likely to experience a nonviable outcome. Overall 82% of the exposed and 93% of the unexposed had at least one live offspring.