Gender Identity and DES Exposure
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Several published studies in the medical literature on psycho-neuro-endocrinology have examined the hypothesis that prenatal exposure to estrogens (including Diethylstilbestrol) may cause significant developmental impact on sexual differentiation of the brain, and on subsequent behavioural and gender identity development in exposed males and females. There is significant evidence linking prenatal hormonal influences on gender identity and transsexual development.

Gender identity and Diethylstilbestrol DES exposure image

There is a possible connection between DES exposure and gender variance

In 1999, Dr. Scott Kerlin (founder of the DES Sons International Network) began researching the effects of Di-Ethyl Stilbestrol® on the health of genetic males who had been exposed prenatally. A substantial amount of research had been done on women who had been exposed but relatively little had been done on men and DES sons. When it became apparent that a significant portion of his research group were either transsexual, transgendered or intersexed, he began to explore the possibility of a connection between prenatal DES exposure and gender variance. Dr. Kerlin is not the first researcher to note a correlation between DES exposure and feminized behaviour in genetic males; studies go back as far as 1973. However, Dr. Kerlin has delved much deeper than those who came before.

Radio Interview: DES Exposure and Gender Variance

Listen to KWMR Radio Interview with Dr. Dana Beyer on the side effects of Diethylstilbestrol and its influence on gender identity

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Dr. Dana Beyer is the medical advisor and web manager of the DES Sons International Network, on the effects of endocrine disrupting compounds such as Diethylstilbestrol, DDT, phthalates and bisphenol A, on human sexuality and reproduction, as well as providing personal support and mentoring. In 2005 she presented a breakthrough paper, with her colleagues Dr. Scott Kerlin and Dr. Milton Diamond, to the International Behavioural Development Symposium, delineating the impact Di-Ethyl Stilbestrol® has had in causing intersex and gender variations in human beings.

I understand this is a sensitive and controversial matter but I feel it is important to bring this issue to light and break the wall of silence around what is still nowadays considered as “taboo”. I would like to invite all DES exposed individuals who have a knowledge of DES exposure and gender identity either through research or personal experience to share their comments and stories.

Take the survey: DES Sons – the Truth and the Unknown Surv it

Sources: DES Sons International Network, TransAdvocate.org

About Dominique “DES Daughter” Le Metayer

Activist, blogger and social media addict committed to shedding light on a global health scandal and dedicated to raise DES awareness.
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15 Responses to Gender Identity and DES Exposure

  1. Carol Devine says:

    Thank you for this very important article, Domino. Here in Australia, the Chameleon Society (WA) is conducting an Australia-wide survey about the extent of DES exposure/usage among those affected by gender issues. This survey for Australians is found at Chameleons WA Discussion Forum.
    Hopefully, as more Australians view your blog, your highlighting this topic will encourage participation in the “survey with regard to Diethylstilboestrol”. Good on you, Domino.
    Carol Devine, DES Exposure Australia

  2. Scott Kerlin says:

    Thank you so very much for your contributions to helping raise further awareness regarding DES Sons. We are always grateful to others who wish to further understand the full range of effects of DES exposure. Interested individuals are encouraged to join our network discussion forum

    With regards,
    Scott Kerlin, Ph.D.
    DES Sons International Network (U.S./Canada)

  3. Anne Thomas says:

    Thanks for researching and sharing such important information.
    Anne Thomas

  4. julie thompson says:

    tell me about grandsons

  5. Hugh Easton says:

    My own opinion is that DES caused intersexed development in the DES sons by blocking testicular testosterone production. DES is a potent chemical castration agent that for many years the treatment of choice for hormone-sensitive prostate cancer. Just 3mg of DES per day is enough to fully chemically castrate an adult man; the starting dose as a miscarriage treatment was 5mg per day (and often went much higher during the later stages of the pregnancy). It’s a not widely appreciated fact, but male development isn’t driven directly by genes, but instead by hormones (primarily testosterone) produced in the testicles of a male fetus. Given the ability DES has to block testosterone production, it’s no surprise that many DES sons are physically and/or psychologically intersexed. The surprising thing is that there’s so little public awareness of it!

    If the problem is just one of testosterone production being suppressed during the critical time sexual development was taking place, then I don’t see any reason for there to be any long term genetic effect or 3rd generation effects. However, one thought that’s occured to me is that DES daughters often have a great deal of difficulty getting pregnant and carrying the pregnancy to term, which puts them at vastly increased risk of medical intervention – and potentially being given hormonal medication during the pregnancy. If one of these hormonal treatments for miscarriage (DES) can cause problems with intersexed development, then the likelihood is that others can too. There’s one drug in particular called hydroxyprogesterone caproate, which is in widespread current use to prevent miscarriages and premature births, and is being given in doses which I’m sure would have some serious gender-bending effects if you were to give the same dose to an adult man.

    In short, although DES was phased out 40 years ago, there’s plenty of other sex hormone derivatives still finding their way inside pregnant women and potentially causing many of the same problems. That’s why I’ve been trying so hard to get people to take me seriously, and see whether there’s a link between exposure to these drugs before birth and endocrine and intersex-related problems later in life!

    • DES Daughter says:

      This is fascinating and so worrying! Thank you for your comment and the work that you do raise awareness of these issues. So much is still unknown and yet it sounds so obvious …

  6. chris johansen says:

    OMFSM
    I have searched for some kind of validation for my GD. I have most of the symptoms for Klienfelders but-nada on the XX
    I even did an ultrasound to confirm what I “knew” since I was in grammar school – That I had female organs in me, but another negative.
    I do know my mother took DES. I do have one small testicle and had a big varicocele that was removed.

    • Pete Mag says:

      You are not alone ever since I was about 5-7 years old I knew something was different.Pretty things where more to my liking but I was teased by my brothers and had to take to more boy type pursuits they were 7 and 8 years older than I.
      Prior to my being born in 1950 my mother had several miscarriages I don’t know for sure if she took DES or not I do know she had a lot of female problems in the years after I was born.As I am the last one left of the old family there is nobody left to ask who might know.The symptoms I have are classic a very large testicle which started developing in my late teens and an overwhelming feeling of being female.I have never even been really able to get turned on like a normal man but if I was treated more like a female slowly and from top to bottom it would set me on fire and my nipples were killers.
      So now after living 63 years as a man I get to go through puberty again and start over as a female.Actually I am looking forward to it after living a lie all those years I need some relief.My wife is very supportive and that is a comfort to me as I don’t know what I would do without her.She never knew but always suspected something when I told her she like 99.9% of the population had no clue that your brain could be female and your body male looking.Oh well ,at least we can go shopping in the women sections and pick out pretty things for me for a change!
      Just for info 6’3″ medium build little fat 175-180lbs full head thick brown hair
      people think I am in my forty’s just wish they thought I was a girl in my forty’s.
      Life is a journey you might as well enjoy it. Peter

  7. veenaga says:

    The symbols above are there in Indian Zodiac signs, the ” + “carrying ‘ O ‘ is Venus the lord of Taurus the Bull power and Libra the symbol for justice. The power and justice can only made justice, Venus is the sperm in spermatozoon, feminine in nature, the queen of the king, who is in the min of the Gemini the best spouses, the sex between them is the output after the friction between the bodies of the spouses, its creation is the satisfaction, after the happiness in the sex. It is the desire, pleasure, artistry, beauty, assets, money and wife hidden in husband.

    The symbol the arrow pulling the ‘ O ‘ up towards the right is the fire, the energy, aggressiveness, machinery, power, injuries and the brother in the female, the male Jupiter in the female, who is the OVA, ” O ” means it sounds calling, ‘VA’ means come in, totally it means welcoming the guest the newly born life, the destiny maker. Ova is natural, and the male in female.

  8. deni Hunter says:

    hi, I’m kind of relieved but freaked out by this info. I identify as transgender, that is, I have always felt that deep down in my soul I was female… DES may be a reason why…i also have other indicators of exposure. It may be the case that my female partner was exposed too. We have one darling son….could there be any effects I need to be aware of for him??
    When will this all become common knowledge? the fact that it isn’t implies litigious potentiality perhaps?…..oh …sad now…:(

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