Here is an example – on this post – with books about the DES tragedy.
DES: The Complete Story
a Book by Cynthia Laitman OrenbergThis prize-winning book provides comprehensive information on every aspect (including legal info) of the drug, DES, the artifical estrogen that was given to millions of pregnant women in the mistaken belief that it would prevent miscarriage. It is clearly written with the consumer in mind, well-organized and still accurate, even more than two decades since its publication. - Sources: Amazon customer review.
Mrs Orenberg, a medical editor and writer for the University of Wisconsin Medical School, has written a treatise on the effects of diethylstilbestrol (DES) from the perspective of a mother whose daughter was exposed in utero to this drug. In 200 pages, she relates in lay terms essentially what is considered to be current knowledge regarding the development of DES, the first inexpensive, orally effective estrogenic substance; the clinical trials carried out by the Smiths in the 1940s regarding its usefulness in certain complications of pregnancy; its subsequent widespread use in several million pregnant women; the controlled double-blind studies that eventually demonstrated it to be no more effective than a placebo; the study in Boston by Herbst, Ulfelder, Scully, and Poskanzer that related exposure in utero to this drug to the development of a rare clear-cell adenocarcinoma of the vagina in several young women; and the subsequent establishment of a ...
Sources: JAMA. 371088 1982;247(14):2027. doi:10.1001/jama.1982.03320390085060.
* Watch DES videos, read more about DES Daughters and DES Sons.
* DES DiEthylSilbestrol Resources by NCBI: Cancer and Pregnancy.
* DES DiEthylSilbestrol Resources by NCBI: In-Utero Exposure to DES.
* All our posts tagged DES and the DES-exposed.
Hormone Disruptors and the Legacy of DES
In 1941 the Food and Drug Administration approved the use of diethylstilbestrol (DES), the first synthetic chemical to be marketed as an estrogen and one of the first to be identified as a hormone disruptor—a chemical that mimics hormones. Although researchers knew that DES caused cancer and disrupted sexual development, doctors prescribed it for millions of women, initially for menopause and then for miscarriage, while farmers gave cattle the hormone to promote rapid weight gain. Its residues, and those of other chemicals, in the American food supply are changing the internal ecosystems of human, livestock, and wildlife bodies in increasingly troubling ways.
In this gripping exploration, Nancy Langston shows how these chemicals have penetrated into every aspect of our bodies and ecosystems, yet the U.S. government has largely failed to regulate them and has skillfully manipulated scientific uncertainty to delay regulation. Personally affected by endocrine disruptors, Langston argues that the FDA needs to institute proper regulation of these commonly produced synthetic chemicals.
Watch the book video trailer - visit the book website More information
* DES Resources: Cancer, Breast Cancer, CCA, Vaginal Cancer.
* DES Resources: Fertility, Pregnancies and Various Studies.
* DES Resources: In-Utero Exposure to DES and DES Side Effects.
* Watch videos, read our posts tagged DES and the DES-exposed.
Gendered Medical Science Producing a Drug for Women
With the publication of The Doctor's Case against the Pill; Witches, Midwives, and Nurses: A History of Women Healers; and Complaints and Disorders: The Sexual Politics of Sickness, in the late 1960s and early 1970s, feminist scholars and activists began to examine ways in which medicine produces diagnoses and treatments that are harmful to women, depicts women in textbooks and scholarly reports in stereotypical and negative ways, and is not objective and value free. Along the way, feminists uncovered ways in which medicine has also been beneficial to women, introducing further complexity into our critique. More recently, feminists have explored how medicine itself is riven with tensions, contradictions, ambiguities, and uncertainties, even at the same time that it retains power in relation to women. Today, feminist scholars are exploring the extent to which medicine is not a monolithic enterprise, while they continue to analyse its consequences and resist those that are negative for women.
This article explores tension in one domain of medicine, It focuses on the links between transformations in medical science and cultural ideas about women using evidence drawn from medical discourse about the safety of the first synthetic oestrogen, DES (diethylstilbestrol). In the 1970s and 1980s, North American feminists undertook the research, political action, and litigation that made DES an infamous instance of medical intervention into women's reproductive lives. Like the Dalkon Shield, DES initially appeared to be a benign and exciting reproductive technology but in the long run had profound and damaging consequences for women.
- Read the book online.
- Flickr albums DES books and DES Research.
More DES DiEthylStilbestrol Resources
- DES studies on cancers and screening.
- DES studies on epigenetics and transgenerational effects.
- DES studies on fertility and pregnancy.
- DES studies on gender identity and psychological health.
- DES studies on in-utero exposure to DES and side-effects.
- DES studies on the genital tract.
- Papers on DES lawsuits.
- DES videos and posts tagged DES, the DES-exposed, DES victims.
Prenatal exposure to progesterone suppresses reproduction in male mice
Partial recovery of reproduction by testosterone
The role of androgens in development of male reproductive organs is well documented. The role of estrogens in the development of male reproductive organs remains largely unknown; although both estrogen receptors and aromatase enzyme have been identified in the developing penis of a number of species, including humans.
Male offspring of women exposed to diethylstilbestrol during pregnancy have higher incidences of epididymal cysts, cryptorchidism, hypospadiasis, and smaller testes.
Since female hormones were routinely prescribed to treat threatened pregnancy and considering the potential implications of female hormones during prenatal period on the development of male reproductive system, the present book describes the effect of prenatal exposure to progesterone on adult male reproduction.
Significant deterioration in reproduction was observed in mice exposed to progesterone during embryonic development which includes reduction in steroidogenesis and spermatogenesis. Testosterone supplementation during post-natal period partially restored the suppressed reproduction.
This 2011 book provides valuable information to those working in mammalian reproduction and also to the interested layman.
More DES DiEthylStilbestrol Resources
DES studies on cancer, breast cancer, CCAC, vaginal cancer, screening.
DES studies on fertility, gender identity, pregnancy.
DES studies on in-utero exposure to DES and DES side-effects.
DES articles on lawsuits and various studies.
Our posts tagged DES, the DES-exposed and DES victims.
Watch DES videos, read more about DES Daughters and DES Sons.