Complications of pregnancy in mice exposed prenatally to DES

To see whether the mouse model replicates impaired reproductive performance in DES-exposed women, a study of reproduction was performed in CD-2 mice

image of lab-mouse
Since the frequency of successful pregnancies in the DES-exposed mice was reduced below control levels to a degree similar to that reported for DES-exposed women, the validity of the mouse model has been confirmed for this characteristic.

Abstract

Complications of pregnancy in mice exposed prenatally to DES, Teratology, NCBI PubMed PMID: 6845221, 1983 Feb.

Women exposed prenatally to diethylstilbestrol (DES) develop a variety of reproductive tract anomalies. Most of these anomalies have been replicated in strain CD-1 mice after similar DES exposure.

Recently, impaired reproductive performance in DES-exposed women has been reported. To see whether the mouse model also replicates this defect, a study of reproduction was performed. Pregnant CD-1 mice were injected with DES and their female offspring were raised to breeding age. The latter were then exposed continuously to untreated males for a maximum of 4 months.

Among 74 mated mice,

  • 34 became pregnant
  • and 11 of these pregnancies ended in abortion or stillbirth.

Other anomalies encountered were:

  • two fetuses with compressed heads,
  • one of which seemed blocked from delivery by a vaginal adenocarcinoma;
  • two uterine tumors,
  • one of which was a teratocarcinoma;
  • two teratomas located in uterine lumina;
  • and two uteri containing placentas without embryos.

Since the frequency of successful pregnancies in the DES-exposed mice was reduced below control levels to a degree similar to that reported for DES-exposed women, the validity of the mouse model has been confirmed for this characteristic.

More DES DiEthylStilbestrol Resources

Author: DES Daughter

Activist, blogger and social media addict committed to shedding light on a global health scandal and dedicated to raise DES awareness.

Have your say! Share your views